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Phenotypes and Genotypes The Search for Influential Genes

SKU: 9781447153108

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Additional information

Full Title

Phenotypes and Genotypes The Search for Influential Genes

Author(s)

Florian Frommlet, Małgorzata Bogdan, David Ramsey

Edition
ISBN

9781447153108, 9781447153092

Publisher

Springer

Format

PDF and EPUB

Description

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.