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| Full Title | Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products 1st Edition |
|---|---|
| Author(s) | W.M. Daniewski, D. Ferreira, E.V. Brandt |
| Edition | 1st Edition |
| ISBN | 9783709163665, 9783211832646, 9783709173077 |
| Publisher | Springer |
| Format | PDF and EPUB |
The condensed tannins (syn. polymeric proanthocyanidins) represent a major group of phenolic compounds in woody and some herbaceous plants (1-3). Their exceptional concentrations in the barks and heartwoods of a variety of tree species have resulted in their commercial extraction with the initial objective of applying the extracts in leather manufacture (4). Essentially all of their biological significance, e. g. the protection of plants from insects, diseases and herbivores, and most of the current, e. g. leather manufacture, and also most promising new uses, e. g. pharmaceuticals or wood preservatives, rest on their com plexation with other biopolymers like proteins and carbohydrates, or metal ions (5, 6). Increasing attention has thus been directed to understanding their conformation and conformational flexibility (7-20) in order to explain their biological activity and to provide a basis for further development of uses for these renewable phenolic compounds. Recent developments have also been initiated by the growing realization that the condensed tannins may additionally be credited for the profound health-beneficial properties of tea, fruit juices and red wine. This is mainly due to their in vitro radical scavenging (21) or antioxidant (22) biological properties, while the polymeric proanthocyanidins in red wine have been implicated in protection against cardiovascular disorders (23), e. g. the “French paradox” (24-26). Collectively these ‘positive’ characteristics of the polymeric proanthocyanidins have transformed “a relatively unattractive and therefore neglected area of study” (27) into, yet again, a fashionable research field.
Original price was: $99.00.$24.99Current price is: $24.99.
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| Full Title | Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 1st Edition |
|---|---|
| Author(s) | D.R. Adams, M. BrochwiczLewinski, A.R. Butler |
| Edition | 1st Edition |
| ISBN | 9783709163511, 9783211831656, 9783709173053 |
| Publisher | Springer |
| Format | PDF and EPUB |
In order to make further progress in elucidating the mechanism of NOS catalysis it will be essential to throw light on the interaction between the enzyme and its substrate. An understanding of the catalytic site will also assist the development of therapeutically important NOS inhibitors. In particular. it will be useful to uncover any differences that exist between the substrate binding sites of the three NOS isozymes which might be exploited for the development of isoform selective NOS inhibitors. A comparison of NOS to other Arg-binding proteins has shown no significant sequence homology (159). Moreover, the lack of a 3D structure and absence of significant sequence homology between the NOS oxygenase domain and known cytochromes P450 has made it difficult to identify residues and construct a model of the distal heme pocket responsible for substrate binding. However, a number of groups are currently working towards crystallisation of the separate NOS reductase and oxygenase domains of the three isoforms for X-ray diffraction studies; the first X-ray structure is likely to be forthcoming within a matter of months. * The results of these studies are expected to resolve many of the uncertainties surrounding the structure of the NOS catalytic site. Preliminary X-ray diffraction analysis of CPR from rat liver has already been reported by MASTERS et al. (524) and the future emergence of a detailed structure for this protein should throw light on the structure and function of the NOS reductase domain.
Original price was: $99.00.$24.99Current price is: $24.99.
Access Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 1st Edition Now. Discount up to 90%
| Full Title | Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 1st Edition |
|---|---|
| Author(s) | W. Herz, H. Falk, G. W. Kirby |
| Edition | 1st Edition |
| ISBN | 9783709161968, 9783211835180, 9783709172490 |
| Publisher | Springer |
| Format | PDF and EPUB |
The volumes of this classic series, now referred to simply as “Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
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