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| Full Title | Computational Methods for Processing and Analysis of Biological Pathways |
|---|---|
| Author(s) | Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos |
| Edition | |
| ISBN | 9783319538686, 9783319538679 |
| Publisher | Springer |
| Format | PDF and EPUB |
This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.
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